دوره 1، شماره 1 و 2 - ( 1-1371 )                   جلد 1 شماره 1 و 2 صفحات 60-54 | برگشت به فهرست نسخه ها

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سبحانی دکتر عبدالرسول. اپوئید‌‌ها(Opioids) و دستگاه گوارش. مجله علوم پزشکی گیلان. 1371; 1 (1 و 2) :54-60

URL: http://journal.gums.ac.ir/article-1-2026-fa.html


استادیار فارماکولوژی- دانشگاه علوم پزشکی گیلان- دانشکده پزشکی- گروه فارماکولوژی
چکیده:   (1520 مشاهده)
SUMMARY
The term opioid was coined to refer in a generic sense to all drugs, natural and synthetic, with morphin - like actions. Three distinct families of peptides have been identified so far in gastrointestinal (GI) nervous system in mammalian.
These peptides include : dynorphin, Met - enkephalin and leu - enkephalin .
Results from studies about opioid which have been started 15 years ago , depend on species , dosages, route of administration and laboratory techniques. Nerve fibers are observed in different parts of GI tract by antiopioid antibody , radioimmunoassay and immunocytochemistry.
The myentric plexus, mucosa , submucosa, circular and longitudinal smooth muscle and perivertebral ganglion of sympathics are innervated by dymorphin and enkephalinergic fibers .
Effect of endogenous opioid are accomplished by special receptors that 8 types of them are known so far. Mu - 1 µ_1) and delta (δ) receptors are preferentially responsible for the effects of opioid in human GI tract. physiological and pharmacological properties of endogenous opioid in different parts of GI tract such as motility and secretion are
hotels Bed dionicced in this article about.
 
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مقاله مروری: پژوهشي | موضوع مقاله: تخصصي
دریافت: 1398/1/20 | پذیرش: 1398/1/20 | انتشار: 1398/1/20

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