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Abstract Introduction: Salive plays an important role in oral homeostasis. Quantitative and qualitative variation in salivary secretion can cause dental caries and periodontal disease. The decrease of saliva may be caused by disease and drugs such as Sjogren Syndrome and Antidepressant drugs. Objective: Compare the quantitative variation of unstimulated salivary rate in smoker and non smoker males. Materials and Methods: This study was case- control .220 people were evaluated in two groups. Group A were 110 subject male smokers, and group B were 110 subject male non smokers. The subjects had 20-55 years old. The evaluation was based on questionnaire. Heavy smokers have been considered as a target group after completing the questionnaire according to systemic disease and HAD test. After gathering necessary characteristics, they were selected as a case group. Non smoker subjects were selected as a control group. Then in a silent place without any disturbing agent such as stress or tiredness, the salivary rate of subjects was collected by spitting method. Data were analyzed by t – test. Results: The mean age of the smoker subjects were 34.3 and the mean age of nonsmoker subjects were 34.7. The saliva average was 1.2 ml in 3 minutes in case group and 1.7 ml in 3 minutes in the control group. This study showed that the amount of saliva in smoker subjects was less than nonsmoker subjects, and this difference was statistically significant (P< 0/05). Conclusion: According to this study, smoking can cause reduction in unstimulated salivary secretion. Therefore, correct oral and dental hygiene instructions should be emphasized for these patients.

Keywords: Month Diseases, Saliva, Smoking

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