Volume 33, Issue 2 (6-2024)
JGUMS 2024, 33(2): 240-253 |
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Shokri B, Bagheri Bavandpouri S R, Asadzade S, Alimohammadi E. Investigating the Factors Associated With Poor Clinical Outcomes of Children With Moderate to Severe Traumatic Brain Injury: A Retrospective Observational Study. JGUMS 2024; 33 (2) :240-253
URL: http://journal.gums.ac.ir/article-1-2622-en.html
URL: http://journal.gums.ac.ir/article-1-2622-en.html
1- Clinical Research Development Center, Taleghani Hospitals, Imam Ali Hospitals, Kermanshah University of Medical Sciences, Kermanshah,Iran.
2- Department of Neurosurgery, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
3- Medical doctor, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
2- Department of Neurosurgery, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
3- Medical doctor, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Abstract: (1873 Views)
Background Traumatic brain injury (TBI) is a leading cause of mortality and disability in pediatric patients. Predicting clinical outcomes following TBI is essential for providing appropriate treatment and improving patient care.
Objective This retrospective study investigates the factors associated with clinical outcomes in children with moderate to severe TBI.
Methods This study evaluated the clinical data of 374 children with TBI who received treatment at our center between May 2014 and May 2021. Clinical, laboratory, and radiographic data were extracted and analyzed. Clinical outcomes were assessed using the Glasgow outcome scale. The patients were divided into two groups as follows: Subjects with favorable clinical outcomes (Glasgow outcome scale=4 and 5), and subjects with poor clinical outcomes (Glasgow outcome scale=1, 2, and 3). Logistic regression analysis was performed to evaluate the relationship between different variables and clinical outcomes.
Results A total of 374 children with moderate to severe TBI were included in the study, consisting of 197 (52.7%) boys and 177 (47.3%) girls. The mean age at the time of trauma was 7.37±3.11 years. According to the logistic regression model, the Glasgow coma score (OR=3.22; 95% CI=1.78-5.24; P<0.001), pupillary response to light (OR=1.97; 95% CI=1.34-2.99; P=0.024), and Rotterdam computed tomography score (OR=2.61; 95% CI=1.72-4.13; P=0.020) were significantly associated with clinical outcomes in children with moderate to severe TBI.
Conclusion The Glasgow coma score, pupillary response to light, and Rotterdam computed tomography score may serve as indicators of poor clinical outcomes in children with moderate to severe TBI. These results can be utilized to enhance the management and care provided to these patients.
Objective This retrospective study investigates the factors associated with clinical outcomes in children with moderate to severe TBI.
Methods This study evaluated the clinical data of 374 children with TBI who received treatment at our center between May 2014 and May 2021. Clinical, laboratory, and radiographic data were extracted and analyzed. Clinical outcomes were assessed using the Glasgow outcome scale. The patients were divided into two groups as follows: Subjects with favorable clinical outcomes (Glasgow outcome scale=4 and 5), and subjects with poor clinical outcomes (Glasgow outcome scale=1, 2, and 3). Logistic regression analysis was performed to evaluate the relationship between different variables and clinical outcomes.
Results A total of 374 children with moderate to severe TBI were included in the study, consisting of 197 (52.7%) boys and 177 (47.3%) girls. The mean age at the time of trauma was 7.37±3.11 years. According to the logistic regression model, the Glasgow coma score (OR=3.22; 95% CI=1.78-5.24; P<0.001), pupillary response to light (OR=1.97; 95% CI=1.34-2.99; P=0.024), and Rotterdam computed tomography score (OR=2.61; 95% CI=1.72-4.13; P=0.020) were significantly associated with clinical outcomes in children with moderate to severe TBI.
Conclusion The Glasgow coma score, pupillary response to light, and Rotterdam computed tomography score may serve as indicators of poor clinical outcomes in children with moderate to severe TBI. These results can be utilized to enhance the management and care provided to these patients.
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Received: 2023/07/17 | Accepted: 2023/11/22 | Published: 2024/06/30
Received: 2023/07/17 | Accepted: 2023/11/22 | Published: 2024/06/30
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