Volume 33, Issue 2 (In-Press 2024)
JGUMS 2024, 33(2): 0-0 |
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Ethics code: 1400.389
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Mohamadianamiri M, Sourati A, Aklamli M. Comparison of the therapeutic effect of boric acid and fluconazole in the treatment of vaginal candidiasis. JGUMS 2024; 33 (2)
URL: http://journal.gums.ac.ir/article-1-2626-en.html
URL: http://journal.gums.ac.ir/article-1-2626-en.html
1- Department of Obstetrics and Gynecology, Endometriosis Research Center, Shahid Akbar-Abadi Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
2- Radiotherapy Department, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran , ainazsourati@yahoo.com
3- Department of Anesthesiology, Shahid Akbar-Abadi Clinical Research Development Unit, , Shahid Akbar-Abadi Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran,
2- Radiotherapy Department, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran , ainazsourati@yahoo.com
3- Department of Anesthesiology, Shahid Akbar-Abadi Clinical Research Development Unit, , Shahid Akbar-Abadi Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran,
Abstract: (245 Views)
Background: Candida vaginitis is the second most common cause of vaginitis in women after bacterial vaginitis. Among the approved treatments, boric acid has been proposed as an effective treatment in drug resistance and disease recurrence.
Objective: This study has compared the effectiveness and side effects of boric acid and fluconazole in the treatment of candida vaginitis.
Methods: In this non-random study, 50 women with candida vaginitis, based on clinical and laboratory examinations from Iranian university hospitals were Convenience sampling in the study. The patients were randomly divided into two groups, one group received oral fluconazole 150 mg for 3 days and the other group received boric acid suppository 600 mg for 14 days. Improvement was identified by laboratory tests. Analysis and statistical analysis was done with the help of descriptive tests of frequency, frequency percentage, mean, dispersion index, standard deviation and chi-square.
Improvement was identified by laboratory tests.
Results: Seven people from the fluconazole group and five people from the boric acid group still had a positive culture after the end of the treatment period, and the response to the treatment was 78% with boric acid and 69.5% with fluconazole (p=0.023). Two people from the boric acid group and three people from the fluconazole group had complications during the treatment, and this difference was not significant (P>0.05).
Conclusion: Fluconazole and boric acid both improve bacterial vaginitis. But the success rate of boric acid treatment is higher. Also, the frequency of complications in the group receiving boric acid was less, which can result in the success of treatment with boric acid.
Objective: This study has compared the effectiveness and side effects of boric acid and fluconazole in the treatment of candida vaginitis.
Methods: In this non-random study, 50 women with candida vaginitis, based on clinical and laboratory examinations from Iranian university hospitals were Convenience sampling in the study. The patients were randomly divided into two groups, one group received oral fluconazole 150 mg for 3 days and the other group received boric acid suppository 600 mg for 14 days. Improvement was identified by laboratory tests. Analysis and statistical analysis was done with the help of descriptive tests of frequency, frequency percentage, mean, dispersion index, standard deviation and chi-square.
Improvement was identified by laboratory tests.
Results: Seven people from the fluconazole group and five people from the boric acid group still had a positive culture after the end of the treatment period, and the response to the treatment was 78% with boric acid and 69.5% with fluconazole (p=0.023). Two people from the boric acid group and three people from the fluconazole group had complications during the treatment, and this difference was not significant (P>0.05).
Conclusion: Fluconazole and boric acid both improve bacterial vaginitis. But the success rate of boric acid treatment is higher. Also, the frequency of complications in the group receiving boric acid was less, which can result in the success of treatment with boric acid.
Review Paper: Applicable |
Subject:
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Received: 2023/08/5 | Accepted: 2024/02/14 | Published: 2024/06/30
Received: 2023/08/5 | Accepted: 2024/02/14 | Published: 2024/06/30
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