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Abstract Introduction: The value of clinical use of tumor markers for prediction of breast cancer recurrence in follow-up or level of response to treatment is still controversial. Objective: In this study, the role of tumor markers in breast cancer recurrence was evaluated. Materials and Methods: One hundred and forty-one breast cancer patients were entered into the study and followed up for 132 months (mean= 34.0، SD= 28.0). The mean age of the patients at time of diagnosis was 47.1 (SD= 12.3) ranging from 23 to 81 years. Most patients (51%) were presented with stage II breast cancer. 81% of the patients underwent modified radical mastectomy and the remaining 19% had breast preservation surgery. The association between clinical recurrence with age, tumor size, nodal involvement, stage, type of surgery and pathology, CA15.3, CEA, P53, ER, PR, and HRE-2 status were examined by using the forward conditional logistic regression analysis. Results: Recurrence occurred in 22% of patients during the follow up time. The results indicated that recurrence was significantly predicted by the status of CA15.3 (odds ratio= 6.1، 95% CI= 1.62-23.1, P= 0.007). Conclusion: The findings showed that independent of age and other known prognostic factors CA 15.3 is an individual factor for prediction of recurrence in breast cancer patients.

Keywords: Breast Cancer, Recurrence, Tumor Markers-Biological

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